Evaluate physical and biophysical properties of small organic compounds, peptides and proteins relevant to oral and parenteral drug delivery; communicate the interpretation and implication of results to clients
Design experiments to develop pre-clinical and clinical formulations for oral and parenteral administration of drug candidates to support drug discovery and development
Design experiments to determine the stability of organic compounds in prototype clinical formulations, to detect and identify the decomposition products, and to achieve formulations with acceptable shelf-life
Maintain a strong awareness of current scientific literature and actively apply new concepts as appropriate
Perform laboratory experiments related to the above.
CLIENT INTERACTION RESPONSIBILITIES:
Interface with clients to develop an in depth understanding of client objectives and define solutions to meet their program requirements
Develop compelling approaches and solutions to address client needs
Write persuasive proposals for the projects
Regularly interact with clients to keep them abreast of project progress
Write and review interim and final reports
SUPERVISORY RESPONSIBILITIES:
Supervise and effectively develop direct reports
REQUIRED BACKGROUND AND EXPERIENCE:
Bachelor’s or Master’s degree in Pharmaceutical Chemistry, Protein Biochemistry, Analytical Chemistry or closely related discipline
Three (3) to Ten (10) years of experience in drug development from the post discovery phase to the initial clinical trials phase
In depth expertise in analytical chemistry and the physicochemical properties of small molecules, and/or peptides and proteins as they relate to the pre-formulation and formulation development of new drugs
A demonstrated drive to apply technical knowledge to developing drug delivery systems and formulations
Established track record of significant contributions as an individual technical expert as well as a leader of small teams
Outstanding written and oral communication skills as well as polished and persuasive client presentation skills
ADDITIONAL DESIRABLE BACKGROUND OR EXPERIENCE:
Experience with pharmaceutics support to discovery and early development, particularly in the areas of parenteral and oral delivery
In depth drug development expertise in two or more of the following formulation types: liquid, lyophilized, dispersed systems, solids, and/or semi-solids
Expertise in salt selection
Expertise in HPLC analysis
Experience with a variety of dry granulation equipment
Experience in oral and parenteral formulation development and pre-formulation studies
Demonstrated capability with pharmacokinetic models for predicting exposure following oral or parenteral administration
Capability with LC/MS, DSC, TGA, lyophilization
Expertise in oral solution and oral suspension dosage form development
Ability to propose realistic reaction mechanisms for drug degradation at ambient conditions prior to identification of actual decay products
Facility with computational chemistry tools to predict physical properties.
Interested candidates are requested to email a copy of their resume with a cover letter including salary history to:rick.eastwick@wolfelabs.com.
Wolfe Laboratories, Inc. (WLI), located in Watertown, MA, is a contract research and development organization that provides services to the pharmaceutical and biotechnology industries. We partner with drug discovery organizations to solve scientific challenges and accelerate the growth of IP. Our services are focused on the transition of small molecule and protein therapeutics from discovery research to early clinical development. These services include analytical/bioanalytical method development, qualification and validation, in vitro DMPK, preformulation, formulation development and optimization, process development and optimization, stability testing, finished product testing, and product complaint testing. We have extensive experience in preformulation and develop liquid, lyophilized, dispersed systems, solids, and semi-solid dosage formulations. We work closely with prospective clients to build the appropriate scope and design of projects, and assist in technology transfer to manufacturing facilities.
We have had a steady 10-year track record of growth, success and profitability.
