Wolfe Laboratories - Pharmacokinetic Analysis

In-vitro ADME Screens
  Aqueous Solubility
  Plasma Stability
  Protein Binding
  Microsome Stability
  CYP450
  Permeability
Pharmacokinetic Analysis
  Bioanalytical Method Development
  Biological Fluid Sample Analysis
  Tissue Analysis
Metabolite Identification

>	CASE STUDY 1 Advancement of an Early Development Candidate to Phase IIb Trials
>	CASE STUDY 2 Development of a Parenteral Formulation of a Cytotoxic Natural Product
>	CASE STUDY 3 Oral Formulation Development for Proof-of-Concept Animal Toxicology Studies
>	CASE STUDY 4 cGMP Analytical Release Testing of a Cytotoxic Drug, as Well as Other Analytical and Bioanalytical Services
>	CASE STUDY 5 Parenteral Dosage Form Development of a Highly Insoluble Molecule

Tissue Analysis

As part of our bioanalysis and pharmacokinetic services, Wolfe Laboratories offers tissue analysis. We are experienced in extracting test compound from tissues (brain, eyes, liver, lungs, etc.) in support of in vivo studies and performs the analysis using modern LC-MS/MS instrumentation. We analyze tissues prepared and supplied directly by clients and can also coordinate the in-life studies through collaborations with independent animal facilities to obtain samples of interest that we prepare and analyze. Wolfe Laboratories provides pharmacokinetic evaluation using WinNonlin® for the determination of standard PK parameters using non-compartmental analysis.