Wolfe Laboratories - From Concept to Creation with Confidence

In-vitro ADME Screens
  Aqueous Solubility
  Plasma Stability
  Protein Binding
  Microsome Stability
  CYP450
  Permeability
Pharmacokinetic Analysis
  Bioanalytical Method Development
  Biological Fluid Sample Analysis
  Tissue Analysis
Metabolite Identification

>	CASE STUDY 1 Parenteral dosage form development of a highly insoluble molecule
>	CASE STUDY 2 Salt form optimization and lyophilized parenteral formulation development
>	CASE STUDY 3 Oral liquid formulation development
>	CASE STUDY 4 Accelerated stability studies to support a screening IND
>	CASE STUDY 5 Lead Optimization: Solubility and formulation screen for efficacy and PK studies

In Vitro ADME and PK Support

Advancing a compound that has the right balance of properties into pre-clinical development is an important consideration for the success of any drug discovery program. In addition to potency and selectivity, solubility, stability and permeability are important ADME factors that play an important role in determining a successful program outcome.

We understand the urgency in generating high quality data to advance your discovery programs in a timely manner and have established a core group of services to meet these needs. Our staff is dedicated to a highly interactive and collaborative relationship with our clients to assure that the individual needs of your program are appropriately addressed.

Our state-of-the-art laboratory includes the ABI 4000 Q Trap™ LC/MS/MS system that has the highest sensitivity for low level quantification.