Wolfe Laboratories - From Concept to Creation with Confidence

In-vitro ADME Screens
   Aqueous Solubility
   Plasma Stability
   Protein Binding
   Microsome Stability
   CYP450
   Permeability
Pharmacokinetic Analysis
  Bioanalytical Method Development
  Biological Fluid Sample Analysis
  Tissue Analysis
Metabolite Identification

>	CASE STUDY 1 Characterization of a Protein Therapeutic Using Mass Spectrometry
>	CASE STUDY 2 Discovery Pharmacokinetic (PK) Studies to iIdentify a Lead Compound
>	CASE STUDY 3 Characterizing Impurities in a New Formulation or Device

Metabolite Identification

Wolfe Labs identifies phase I and phase II metabolites in samples from both in vitro and in vivo sources. In addition to identifying the general types of metabolites by LC/MS, the sites of biotransformation can be deduced from MS/MS data.