Wolfe Laboratories - From Concept to Creation with Confidence

In-vitro ADME Screens
   Aqueous Solubility
   Plasma Stability
   Protein Binding
   Microsome Stability
   CYP450
   Permeability
Pharmacokinetic Analysis
  Bioanalytical Method Development
  Biological Fluid Sample Analysis
  Tissue Analysis
Metabolite Identification

>	CASE STUDY 1 Characterization of a Protein Therapeutic Using Mass Spectrometry
>	CASE STUDY 2 Discovery Pharmacokinetic (PK) Studies to iIdentify a Lead Compound
>	CASE STUDY 3 Characterizing Impurities in a New Formulation or Device

Bioanalytical Method Development

Wolfe Labs develops highly sensitive and robust LC/MS/MS methods to measure test compound levels in all types of fluids and tissues from a variety of species, including rodents, canines and primates. We also optimize existing methods to improve sensitivity and selectivity (e.g., reduce the LLOQ, improve S/N, enhance the extraction procedure, etc.). Various levels of development and qualification are available, from early discovery to ready for validation as GLP, depending on the needs of the program.